Vol. 7, Issue 1, Part A (2025)

Charcot neuroarthropathy is a devastating joint condition that affects persons with neuropathy. With HIV/AIDS treatments prolonging the lives of these persons, it is likely that long-term sequelae of the disease will become more evident in the near future. Patients with this disease frequently develop peripheral neuropathy. A high index of suspicion must be raised in any patient with peripheral neuropathy of any cause and a red, hot, swollen, painful foot for Charcot neuroarthropathy to give these patients proper treatment to help prevent the devastating effects of Charcot Neuroarthropathy with its potential consequences including foot ulceration and amputation. We present a case of an individual with toxic polyneuropathy associated with antiretroviral therapy inducing Charcot Neuroarthropathy.