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International Journal of Orthopaedics and Physiotherapy

Vol. 6, Issue 1, Part A (2024)

Prophylactic anticoagulants in arthroplasty: Review of article

Author(s):

Muthanna Abdul Razaq, Saher Habeeb Qaryaqos and Mohanad Adnan Bakr

Abstract:

Background: Venous Thromboembolism (VTE) is a significant condition that is known to be present after total hip or knee replacement, and anticoagulants therapy as a prophylaxis is currently the treatment option. The study was carried to assess the efficacy of various anticoagulants in the reduction-of-individual VTE risk after these operations.
Objectives: To carry out detailed network meta-analysis of effectiveness of all anticoagulants for the prevention of VTE after total hip or knee arthroplasty.
Methods: One systematic review, network meta-analysis of the mentioned studies was performed, in which anticoagulant medications was given after total hip or knee arthroplasty. The main outcome measures were Deep vein thrombosis (DVT) and pulmonary embolism (PE).
Results: The study evaluation process comprised 18 studies looking at the effects of eight anticoagulants. Regarding DVT prevention, apixaban, edoxaban, fondaparinux, and rivaroxaban proved to be more effective than other agents in this class. There were no signifcant differences in respect of PE prevention for the anticoagulants.
Conclusion: This systematic evaluation revealed a better efficiency of apixaban, edoxaban, fondaparinux and rivaroxaban in preventing DVT following THA/TKA than the other anticoagulants. The use of NOACs would increase the effectiveness of patient management and reduce the morbidity of DVT.
 

Pages: 38-43  |  63 Views  27 Downloads


International Journal of Orthopaedics and Physiotherapy
How to cite this article:
Muthanna Abdul Razaq, Saher Habeeb Qaryaqos and Mohanad Adnan Bakr. Prophylactic anticoagulants in arthroplasty: Review of article. Int. J. Orthop. Physiother. 2024;6(1):38-43. DOI: 10.33545/26648989.2024.v6.i1a.25
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